Neutrolis’ unique approach allows for detailed interrogation of NET-based diseases and development of first-in-class therapeutics.
Detailed mechanistic understanding of neutrophil diseases using proprietary humanized mouse models
In silico and rational design of therapeutic candidates targeted to disease mechanisms
Identification of genetically relevant patient populations using real-world evidence to enable the most efficient validation and characterization of clinical impact
Rapid iterative prototyping and scalable manufacturing of lead molecules for clinical development
Measurement of biomarkers for patient stratification and assessment of pharmacodynamic effects of therapeutic candidates
Neutrolis systematically identifies biomarkers that provide high confidence in the selection, treatment and monitoring of patients that are candidates for Neutrolis’ therapies. We leverage real-world evidence, genetics, and biomarkers to clearly define populations at a genetic and physiological level. Neutrolis uses robust detection methods to select patients likely to respond to anti-NETs therapies. In addition to patient stratification, our pharmacodynamic biomarkers also allow us to monitor treatment response to our therapies.
In patients with inflammatory or autoimmune diseases, such as lupus, NETs are formed in tissues and organs. Due to low levels of intrinsic NET disassembly, small fragments of NETs circulate in the blood.
Blood drawn and processed from patients will contain NET fragments, which are indicative of Neutrolis' drug target exposure.
Molecular biomarker analysis on NET fragments provide additional insights into treatment strategies for patients.