About

Pioneers in NETosis

Neutrolis is a clinical stage therapeutics company targeting Neutrophil Extracellular Traps (NETs) and other sources of pathologic extracellular DNA.

150 Years of Progress

The role of DNA as a key component of the human immune response has been observed for over 150 years. The specific mechanistic understanding of DNA’s involvement with disease, however, was a puzzle that took decades and significant scientific advancement to elucidate. With the discovery of NETs in 2004, it became clear that this fundamental and pathological source of extracellular DNA required improved therapeutic management.

Building on the precedent of previous DNASE therapies, which mainly targeted bacterial sources of DNA, Neutrolis is developing therapies that are capable of treating the scale and structure of extracellular DNA produced by NETosis. The company’s pipeline includes molecules generated by the exDNASETM platform that remove NETs and halt their pathologic effects.

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DNA first discovered in pus
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First lupus patient dosed with DNASE treatment
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Approval of Pulmozyme (rDNASE1)
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Discovery of NETs by Dr. Arturo Zychlinsky at the Max Planck Institute
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"NETosis" first described by Dr. Toby Fox
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NETs role in autoimmunity described by Dr. Abdul (Hakkim)
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Incorporation of Neutrolis
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First patient dosed with Neutrolis therapies

The Neutrolis Story

Neutrolis was founded in 2017 by Drs. Toby Fox and Abdul (Hakkim), two of the earliest and most-cited leaders in the NETs field. Toby and Hakkim have collaborated for over 18 years starting as molecular biologists in the lab of Dr. Arturo Zychlinsky at The Max Planck Institute for Infection Biology, who characterized NETs in a 2004 cover article in Science. After establishing careers in academia and industry, Toby and Hakkim cofounded Neutrolis to commercialize the innovative exDNASETM platform based on their unique understanding of NETs clearance mechanisms. Neutrolis is a clinical stage company developing a robust pipeline of therapeutics in major disease areas driven by NET-based pathologies starting with lupus.

Neutrolis Highlights

5+
years in operation 
17+
years of foundational
R&D in NETs 
$45M
raised to date
$33M
Series A in 2021
5
awards received from BMS, Pfizer and NIH

Founders

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Team

Anthony Aiudi, PharmD
CEO

Anthony Aiudi, PharmD

CEO
Toby Fox, PhD
Co-founder, Co-president & CSO

Toby Fox, PhD

Co-founder, Co-president & CSO
Abdul Hakkim, PhD
Co-founder, Co-president & COO

Abdul Hakkim, PhD

Co-founder, Co-president & COO
Andreas Reiff, MD
CMO

Andreas Reiff, MD

CMO
Ralph Lambalot, PhD
CTO

Ralph Lambalot, PhD

CTO
Ken Olivier Jr., PhD
EVP of Development

Ken Olivier Jr., PhD

EVP of Development
Ghazaleh Gouya Lechner, MD
Head of Clinical Operations

Ghazaleh Gouya Lechner, MD

Head of Clinical Operations

Board of Directors

Gerald Chan, SD

Gerald Chan, SD

John Sundy, MD

John Sundy, MD

Anthony Aiudi, PharmD
CEO

Anthony Aiudi, PharmD

CEO
Toby Fox, PhD
Co-founder, Co-president & CSO

Toby Fox, PhD

Co-founder, Co-president & CSO
Abdul Hakkim, PhD
Co-founder, Co-president & COO

Abdul Hakkim, PhD

Co-founder, Co-president & COO

Scientific and Medical Advisory Board

Denisa Wagner, PhD
Senior Investigator, Program in Cellular and Molecular Medicine; Professor of Pediatrics, Harvard Medical School

Dr. Denisa Wager is a professor of medicine at Harvard Medical School, a senior investigator in the Program in Cellular and Molecular Medicine, and a member of the Division of Hematology/Oncology at Boston Children's Hospital.

Dr. Wagner is a key opinion leader in the field of NETs with #XXX publications in this space. She brings deep understanding of vascular biology, adhesion molecules and inflammatory pathways to Neutrolis and is a co-inventor on core aspects of Neutrolis’s proprietary technology.

Her research efforts have uncovered foundational aspects of how pathogenic NETs influence both acute and chronic disorders in humans.  These disorders include (thrombosis, atherosclerosis, reperfusion injury, wound healing, cancer associated thrombosis, stroke and ALI.